Biodiesel was synthesized with the ester exchange reaction from animal oil and methanol catalyzed by solid super base. The influence of the molar ratio of alcohol and oil, quantity of catalyst, reaction time and temperature was investigated. The experimental results show that the optimum condition is the mass fraction of catalyst in animal oil 2% , the reaction time 3 h, the reaction temperature 70 ℃ and the molar ratio of alcohol to oil 9∶1.